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Rosmarinic Acid Attenuates Sodium Taurocholate-Induced Acute Pancreatitis in Rats by Inhibiting Nuclear Factor-κB Activation.

Authors :
Fan, Yu-Ting
Yin, Guo-Jian
Xiao, Wen-Qin
Qiu, Lei
Yu, Ge
Hu, Yan-Ling
Xing, Miao
Wu, De-Qing
Cang, Xiao-Feng
Wan, Rong
Wang, Xing-Peng
Hu, Guo-Yong
Source :
American Journal of Chinese Medicine. 2015, Vol. 43 Issue 6, p1117-1135. 19p. 3 Charts, 4 Graphs.
Publication Year :
2015

Abstract

Rosmarinic Acid (RA), a caffeic acid ester, has been shown to exert anti-inflammation, anti-oxidant and antiallergic effects. Our study aimed to investigate the effect of RA in sodium taurocholate ()-induced acute pancreatitis, both in vivo and in vitro. In vivo, RA (50 mg/kg) was administered intraperitoneally 2 h before sodium taurocholate injection. Rats were sacrificed 12 h, 24 h or 48 h after sodium taurocholate injection. Pretreatment with RA significantly ameliorated pancreas histopathological changes, decreased amylase and lipase activities in serum, lowered myeloperoxidase activity in the pancreas, reduced systematic and pancreatic interleukin-1 β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) levels, and inhibited NF-κB translocation in pancreas. In vitro, pretreating the fresh rat pancreatic acinar cells with 80 μ mol/L RA 2 h before 3750 nmol/L sodium taurocholate or 10 ng/L TNF-α administration significantly attenuated the reduction of isolated pancreatic acinar cell viability and inhibited the nuclear activation and translocation of NF-κB. Based on our findings, RA appears to attenuate damage in sodium taurocholate-induced acute pancreatitis and reduce the release of inflammatory cytokines by inhibiting the activation of NF-κB. These findings might provide a basis for investigating the therapeutic role of RA in managing acute pancreatits. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0192415X
Volume :
43
Issue :
6
Database :
Academic Search Index
Journal :
American Journal of Chinese Medicine
Publication Type :
Academic Journal
Accession number :
110203602
Full Text :
https://doi.org/10.1142/S0192415X15500640