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Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 10/1/2015, Vol. 2015, p1-14. 14p. 2 Diagrams, 6 Charts, 1 Graph. - Publication Year :
- 2015
-
Abstract
- Objectives. Preliminary researches showed that luteolin was used to treat hypertension. However, it is still unclear whether luteolin has effect on the hypertensive complication such as vascular remodeling. The present study was designed to investigate the effect of luteolin on the hypertensive vascular remodeling and its molecular mechanism. Method and Results. We evaluated the effect of luteolin on aorta thickening of hypertension in spontaneous hypertensive rats (SHRs) and found that luteolin could significantly decrease the blood pressure and media thickness of aorta in vivo. Luteolin could inhibit angiotensin II- (Ang II-) induced proliferation and migration of vascular smooth muscle cells (VSMCs). Dichlorofluorescein diacetate (DCFH-DA) staining result showed that luteolin reduced Ang II-stimulated ROS production in VSMCs. Furthermore, western blot and gelatin zymography results showed that luteolin treatment leaded to a decrease in ERK1/2, p-ERK1/2, p-p38, MMP2, and proliferating cell nuclear antigen (PCNA) protein level. Conclusion. These data support that luteolin can ameliorate hypertensive vascular remodeling by inhibiting the proliferation and migration of Ang II-induced VSMCs. Its mechanism is mediated by the regulation of MAPK signaling pathway and the production of ROS. [ABSTRACT FROM AUTHOR]
- Subjects :
- *REACTIVE oxygen species
*ANGIOTENSINS
*ANIMAL experimentation
*AORTA
*BLOOD pressure
*CELL culture
*CELL cycle
*CELL migration
*ENZYME-linked immunosorbent assay
*FLAVONOIDS
*HIGH performance liquid chromatography
*HYPERTENSION
*MICROBIOLOGICAL assay
*RATS
*RESEARCH funding
*SMOOTH muscle
*T-test (Statistics)
*TOXICITY testing
*WESTERN immunoblotting
*PLANT extracts
*DATA analysis software
*IN vitro studies
*VASCULAR remodeling
*ONE-way analysis of variance
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2015
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 110311792
- Full Text :
- https://doi.org/10.1155/2015/364876