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Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet.
- Source :
-
Nutrition & Metabolism . 2014, Vol. 11 Issue 1, p15-23. 9p. 3 Charts, 4 Graphs. - Publication Year :
- 2014
-
Abstract
- Background: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet. Methods: Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)]. Results: The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-κB p50. In HC we observed a positive correlation between IL-10 and TNF-α in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue. Conclusions: High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17437075
- Volume :
- 11
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nutrition & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 110322985
- Full Text :
- https://doi.org/10.1186/1743-7075-11-15