Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients.

Discusses a study which aimed to purify and characterize a glycosylated high molecular weight (HMW) allergen from celery, the major elicitor of food allergy in Central Europe. Description of HMW; Correlation between birch, mugwort and celery allergy; Evidence which concerns immunoglobulin E directed to HMW allergens.