Back to Search
Start Over
Large Scale Synthesis of Highly Stable Fluorescent Carbon Dots Using Silica Spheres as Carriers for Targeted Bioimaging of Cancer Cells.
- Source :
-
Particle & Particle Systems Characterization . Oct2015, Vol. 32 Issue 10, p944-951. 8p. - Publication Year :
- 2015
-
Abstract
- In this paper, fluorescent carbon dots (CDs) loaded on silica (SiO2) spheres are synthesized by the one-pot hydrothermal route, and then folic acids (FA) are covalently conjugated on the surface of SiO2 spheres. The formed SiO2@CDs-FA composites can target specific tissues, e.g., cancer. The key of this method is the employment of (3-aminopropyl)trimethoxysilane as bridge joint, which not only serves as surface passivation agents allowing the large scale synthesis of CDs with high quantum yield, but also enables SiO2@CDs composites further covalent conjugation of FA. The resultant SiO2@CDs composites have many advantages such as easy separation and purification, highly stable, well water-soluble, and biocompatible. Moreover, the SiO2@CDs-FA could be used as fluorescent probes for biological imaging in vitro. The uptake of the SiO2@CDs-FA into HeLa cells is receptor-mediated endocytosis, which is confirmed by a comparative study using FR-negative 293T cells. Findings from this study suggest that the SiO2@CDs-FA composites could be used as a platform for cancer diagnosis studies in various biological systems. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09340866
- Volume :
- 32
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Particle & Particle Systems Characterization
- Publication Type :
- Academic Journal
- Accession number :
- 110362414
- Full Text :
- https://doi.org/10.1002/ppsc.201500062