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Sphingomyelinase Activity Causes Transbilayer Lipid Translocation in Model and Cell Membranes.

Authors :
Contreras, F.-Xabier
Villar, Ana-Victoria
Alonso, Alicia
Kolesnick, Richard N.
Goñi, Félix M.
Source :
Journal of Biological Chemistry. 9/26/2003, Vol. 278 Issue 39, p37169-37174. 6p. 1 Chart, 4 Graphs.
Publication Year :
2003

Abstract

Presents a study indicating that the sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes. Description of a novel effect of ceramide, namely the induction of transbilayer lipid movements; Novel assays developed to detect transbilayer lipid movement; Role of sphingomyelinase activity in inducing ganglioside hydrolysis under conditions in which no neuraminidase was released from the vesicles.

Details

Language :
English
ISSN :
00219258
Volume :
278
Issue :
39
Database :
Academic Search Index
Journal :
Journal of Biological Chemistry
Publication Type :
Academic Journal
Accession number :
11051779
Full Text :
https://doi.org/10.1074/jbc.M303206200