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The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus.
- Source :
-
BMC Genetics . 10/16/2015, Vol. 16, p1-6. 6p. - Publication Year :
- 2015
-
Abstract
- Background: Current evidence shows that the CD40-CD40 ligand (CD40-CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investigate whether a CD40 gene single nucleotide polymorphism (SNP) is associated with SLE and CD40 expression in the Chinese population. We included controls (n = 220) and patients with either SLE (n =205) in the study. Methods: The gene polymorphism was measured using Snapshot SNP genotyping assays and confirmed by sequencing. We analyzed three single nucleotide polymorphisms of CD40 gene rs1883832C/T, rs1569723A/C and rs4810485G/T in 205 patients with SLE and 220 age-and sex-matched controls. Soluble CD40 (sCD40) levels were measured by ELISA. Results: There were significant differences in the genotype and allele frequencies of CD40 gene rs1883832C/T polymorphism between the group of patients with SLE and the control group (P < 0.05). sCD40 levels were increased in patients with SLE compared with controls (P < 0.01). Moreover, genotypes carrying the CD40 rs1883832 C/T variant allele were associated with increased CD40 levels compared to the homozygous wild-type genotype in patients with SLE. The rs1883832C/T polymorphism of CD40 and its sCD40 levels were associated with SLE in the Chinese population. Conclusions: Our results suggest that CD40 gene may play a role in the development of SLE in the Chinese population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712156
- Volume :
- 16
- Database :
- Academic Search Index
- Journal :
- BMC Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 110540983
- Full Text :
- https://doi.org/10.1186/s12863-015-0279-8