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Capecitabine and oxaliplatin combined with bevacizumab are feasible for treating selected Japanese patients at least 75 years of age with metastatic colorectal cancer.
- Source :
-
BMC Cancer . 10/24/2015, Vol. 15, p1-10. 10p. 4 Charts, 1 Graph. - Publication Year :
- 2015
-
Abstract
- <bold>Background: </bold>Although number of elderly patients with metastatic colorectal cancer (mCRC) is rapidly increasing, this population is often underrepresented in clinical trials. Recently, a phase II trial demonstrated that capecitabine and oxaliplatin (XELOX) combined with bevacizumab XELOX plus bevacizumab was effective and well tolerated by elderly patients with mCRC who reside in Western countries. The aim of this study was to evaluate the safety and efficacy of XELOX plus bevacizumab for Japanese patients aged ≥ 75 years with mCRC.<bold>Methods: </bold>This prospective, open-label phase II trial recruited patients aged ≥ 75 years with previously untreated mCRC between March 2010 and January 2012. Treatment consisted of 7.5 mg/kg of intravenous bevacizumab and 130 mg/m(2) of oxaliplatin on day 1 of each cycle combined with 2000 mg/m(2) of oral capecitabine per day on days 1-14 of each cycle. Treatment was repeated every 3 weeks until disease progression or termination of the study. The primary endpoint was progression-free survival; the secondary endpoints were toxicity, overall response rate, time-to-treatment failure, and overall survival.<bold>Results: </bold>Thirty-six patients (male 58%; median age 78 years; colon cancer 67%) met all eligibility criteria and received at least one course of the planned treatment. The median time-to-treatment failure was 7.0 months. Twelve patients (33.3%) experienced adverse effects (AEs) ≥ grade 3 and frequent AEs ≥ grade 3, including neutropenia (22.2%) and neuropathy (13.9%). Hypertension was the most frequent AE ≥ grade 3 associated with bevacizumab (11.1%). Low baseline creatinine clearance associated significantly with the incidence of AEs ≥ grade 3. Response and disease control rates were 55.6 and 91.7%, respectively. Median progression-free and overall survival times were 11.7 months (95% confidence interval, 8.0-13.4 months) and 22.9 months, respectively.<bold>Conclusion: </bold>XELOX combined with bevacizumab was well tolerated by selected Japanese patients aged ≥ 75 years with mCRC patients, and controlled clinical trials are now required to determine the survival benefit. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLON cancer patients
*COLON cancer treatment
*CARBAMATE derivatives
*OXALIPLATIN
*BEVACIZUMAB
*COMBINATION drug therapy
*JAPANESE people
*THERAPEUTICS
*DISEASES
*AGE distribution
*ANTINEOPLASTIC agents
*ASIANS
*CLINICAL trials
*COLON tumors
*COMPARATIVE studies
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*NAUSEA
*NEUTROPENIA
*ORGANOPLATINUM compounds
*RESEARCH
*SURVIVAL
*EVALUATION research
*TREATMENT effectiveness
*DIAGNOSIS
RECTUM tumors
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 15
- Database :
- Academic Search Index
- Journal :
- BMC Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 110585388
- Full Text :
- https://doi.org/10.1186/s12885-015-1712-0