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Organocatalytic enantioselective Diels–Alder reaction of 4,4,4-trifluorocrotonaldehyde.
- Source :
-
Journal of Fluorine Chemistry . Nov2015, Vol. 179, p77-82. 6p. - Publication Year :
- 2015
-
Abstract
- A highly enantioselective Diels–Alder reaction of 4,4,4-trifluorocrotonaldehyde and dienes was performed with a diarylprolinol silyl ether catalyst. The reaction with cyclopentadiene, 1,3-cyclohexadiene, and 2-substituted 1,3-butadienes yielded the corresponding cycloadducts bearing a trifluoromethylated chiral carbon center with up to 97% ee, whereas the reaction with furan yielded the corresponding Friedel–Crafts adduct with high enantioselectivity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221139
- Volume :
- 179
- Database :
- Academic Search Index
- Journal :
- Journal of Fluorine Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 110631526
- Full Text :
- https://doi.org/10.1016/j.jfluchem.2015.05.011