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Prevalence of Alpha and Beta-Thalassemia Mutations Among Carriers of Thalassemia in Shadegan City, Southwest of Iran.
- Source :
-
Zahedan Journal of Research in Medical Sciences . Aug2015, Vol. 17 Issue 8, p1-4. 4p. - Publication Year :
- 2015
-
Abstract
- Background: We aimed to investigate the alpha and beta-thalassemia mutations and assess the association of hematologic indices with mutations. Patients and Methods: In this cross sectional study, we assessed 275 suspected thalassemia carriers. Amplification refractory mutation system-polymerase chain reaction and Gap PCRwere used for detection of mutations. Results: CD 36 - 37 (-T) and -α3.7/αα were most common mutations. Mean of corpuscular hemoglobin and corpuscular volume was less among beta-thalassemia carriers in comparison to alpha-thalassemia carriers (P = 0.001). Conclusions: Detected mutations were different from other regions in Iran. After iron therapy, mean of corpuscular volume (MCV) was < 69 fL and mean of corpuscular hemoglobin was < 23 pg, maybe classified as beta-thalassemia carriers. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BETA-Thalassemia
*POLYMERASE chain reaction
*ALPHA-Thalassemia
Subjects
Details
- Language :
- English
- ISSN :
- 20087977
- Volume :
- 17
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Zahedan Journal of Research in Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 110682974
- Full Text :
- https://doi.org/10.17795/zjrms1032