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Multicomponent Synthesis of Functionalized Tetrahydroacridinones:Insights into a Mechanistic Route.
- Source :
-
Organic Letters . Nov2015, Vol. 17 Issue 21, p5368-5371. 4p. - Publication Year :
- 2015
-
Abstract
- A mechanisticstudy of three-component reactions of various aromaticamines with a number of aldehydes and 1,3-diones was achieved. Theunprecedented reaction involved a nucleophilic attack of an aromaticamine on the in situ generated Michael adduct intermediate followedby six-electron ring cyclizations. It is contrary to the common beliefthat advocates involvement of coupling reactions between a Knoevenageladduct and an aromatic amine to deliver substituted tetrahydroacridinones. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 17
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 110803441
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b02705