EphA kinase activiation regulates HGF-induced epithelial branching morphogenesis.

Authors :: Hui Miao
Nickel, Christian
Cantley, Lloyd G.
Bruggeman, Leslie A.
Bernardo, Laura N.
Bingcheng Wang
Source :: Journal of Cell Biology. 9/29/2003, Vol. 162 Issue 7, p1281-1292. 12p. 8 Color Photographs, 3 Black and White Photographs, 1 Diagram, 12 Graphs.
Publication Year :: 2003
Abstract: Reports on Eph kinases and their ephrin ligands which are widely expressed in epithelial cells in vitro and in vivo. Regulation of hepatocyte growth factor/scatter factor (HGF)-induced branching morphogenesis in collagen gel, by the activation of endogenous EphA kinases in Madin-Darby canine kidney (MDCK) cells; Mechanism by which EphA kinase activation inhibits HGF-induced MDCK branching morphogenesis.

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