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In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
- Source :
-
Chemico-Biological Interactions . Oct2015, Vol. 240, p310-315. 6p. - Publication Year :
- 2015
-
Abstract
- Recent epidemiological studies show conflicting data for the first-line anti-diabetic sulphonylureas drugs in treating cancer progression in type II diabetes patients. How sulphonylureas promote or diminish tumor growth is not fully understood. Here, we report that seven sulphonylureas exhibit different in vitro inhibition towards AKR1Cs (AKR1C1, AKR1C2, AKR1C3), which are critical steroid hormone metabolism enzymes that are related to prostate cancer, breast cancer and endometrial diseases. Interactions of the sulphonylureas and AKR1Cs were analyzed by X-ray crystallography. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER chemotherapy
*X-rays
*DRUG therapy
*CANCER treatment
*ELECTROMAGNETIC waves
Subjects
Details
- Language :
- English
- ISSN :
- 00092797
- Volume :
- 240
- Database :
- Academic Search Index
- Journal :
- Chemico-Biological Interactions
- Publication Type :
- Academic Journal
- Accession number :
- 111055706
- Full Text :
- https://doi.org/10.1016/j.cbi.2015.09.006