Back to Search Start Over

Pancreatic ductal adenocarcinoma and chronic mass-forming pancreatitis: Differentiation with dual-energy MDCT in spectral imaging mode.

Authors :
Yin, Qihua
Zou, Xinnong
Zai, Xiaodong
Wu, Zhiyuan
Wu, Qingyang
Jiang, Xingyu
Chen, Hongwei
Miao, Fei
Source :
European Journal of Radiology. Dec2015, Vol. 84 Issue 12, p2470-2476. 7p.
Publication Year :
2015

Abstract

<bold>Objective: </bold>To investigate the value of dual-energy MDCT in spectral imaging in the differential diagnosis of chronic mass-forming chronic pancreatitis (CMFP) and pancreatic ductal adenocarcinoma (PDAC) during the arterial phase (AP) and the pancreatic parenchymal phase (PP).<bold>Materials and Methods: </bold>Thirty five consecutive patients with CMFP (n=15) or PDAC (n=20) underwent dual-energy MDCT in spectral imaging during AP and PP. Iodine concentrations were derived from iodine-based material-decomposition CT images and normalized to the iodine concentration in the aorta. The difference in iodine concentration between the AP and PP, contrast-to-noise ratio (CNR) and the slope K of the spectrum curve were calculated.<bold>Results: </bold>Normalized iodine concentrations (NICs) in patients with CMFP differed significantly from those in patients with PDAC during two double phases (mean NIC, 0.26±0.04 mg/mL vs. 0.53±0.02 mg/mL, p=0.0001; 0.07±0.02 mg/mL vs. 0.28±0.04 mg/mL, p=0.0002, respectively). There were significant differences in the value of the slope K of the spectrum curve in two groups during AP and PP (K(CMFP)=3.27±0.70 vs. K(PDAC)=1.35±0.41, P=0.001, and K(CMFP)=3.70±0.17 vs. K(PDAC)=2.16±0.70, p=0.003, respectively). CNRs at low energy levels (40-70 keV) were higher than those at high energy levels (80-40 keV).<bold>Conclusion: </bold>Individual patient CNR-optimized energy level images and the NIC can be used to improve the sensitivity and the specificity for differentiating CMFP from PDAC by use of dual-energy MDCT in spectral imaging with fast tube voltage switching. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0720048X
Volume :
84
Issue :
12
Database :
Academic Search Index
Journal :
European Journal of Radiology
Publication Type :
Academic Journal
Accession number :
111056616
Full Text :
https://doi.org/10.1016/j.ejrad.2015.09.023