Synthesis of 5H-Pyrrolo[3,4-b]pyrazine-Based Peptidomimetics.

A range of 5H-pyrrolo[3,4-b]pyrazine-based peptidomimetics were designed, and their efficient synthesis starting from 5-imino-5H-pyrrolo[3,4-b]pyrazin-7-amine by subsequent interaction with Nprotected amino acid hydrazides and amino acid esters with N,N-carbonyldiimidazole as the coupling agent was elaborated. [ABSTRACT FROM AUTHOR]