Back to Search
Start Over
Autoantibodies to serotonin in serum of patients with psychiatric disorders
- Source :
-
Psychiatry Research . Nov2003, Vol. 121 Issue 1, p51. 7p. - Publication Year :
- 2003
-
Abstract
- Antibodies to serotonin in serum were investigated by ELISA in patients with paranoid schizophrenia (N=27), schizoaffective psychosis (N=38), depression (N=67), Alzheimer''s disease (N=21), chronic alcoholism (N=43), rheumatoid arthritis (N=25), and multiple sclerosis (N=16), and in healthy volunteers (N=60). Increased antibody reactivity to serotonin was found in schizoaffective psychosis, chronic alcoholism, and rheumatoid arthritis. Decreased antibody reactivity to serotonin was found in multiple sclerosis and depression. These anti-serotonin antibodies belong to the class of so-called natural autoantibodies. Alterations of these natural autoantibodies could indicate a disturbance to the immune system. It is possible that these antibodies could also influence receptor function. Autoantibodies to neurotransmitters in a wide spectrum of psychiatric disorders have not previously been reported. [Copyright &y& Elsevier]
- Subjects :
- *SEROTONIN
*PARANOID schizophrenia
*RHEUMATOID arthritis
Subjects
Details
- Language :
- English
- ISSN :
- 01651781
- Volume :
- 121
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Psychiatry Research
- Publication Type :
- Academic Journal
- Accession number :
- 11114158
- Full Text :
- https://doi.org/10.1016/S0165-1781(03)00137-9