Polyoxygenated steroids from the gorgonian Menella woodin with capabilities to modulate ROS levels in macrophages at response to LPS.

Four new polyoxygenated sterol derivatives ( 1 – 4 ) along with the compounds ( 5 – 7 ) previously known from other biological sources were isolated from the gorgonian Menella woodin , collected from the Vietnamese waters. Structures of 1 – 4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as comparison with those reported in literature data. Compounds 1 , 4 , and 6 decrease the production of reactive oxygen species (ROS) by the murine macrophages of RAW 264.7 line at induction by endotoxic lipopolysaccharide (LPS) from Escherichia coli . [ABSTRACT FROM AUTHOR]