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Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice.
- Source :
-
International Immunopharmacology . Dec2015, Vol. 29 Issue 2, p950-956. 7p. - Publication Year :
- 2015
-
Abstract
- Accumulating evidence reveals that lipopolysaccharide (LPS) can induce neuroinflammation, ultimately leading to cognitive deficits. Mangiferin, a natural glucoxilxanthone, is known to possess various biological activities. The present study aimed to investigate the effects of mangiferin on LPS-induced cognitive deficits and explore the underlying mechanisms. Brain injury was induced in mice via intraperitoneal LPS injection (1 mg/kg) for five consecutive days. Mangiferin was orally pretreatmented (50 mg/kg) for seven days and then treatmented (50 mg/kg) for five days after LPS injection. The Morris water maze was used to detect changes in cognitive function. Immunohistochemical and immunoblotting were respectively performed to measure the expression of interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that mangiferin can ameliorate cognitive deficits. Moreover, mangiferin decreased LPS-induced IL-6 production and increase HO-1 in the hippocampus. Taken together, these results suggest that mangiferin attenuates LPS-induced cognitive deficits, which may be potentially linked to modulating HO-1 in the hippocampus. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 29
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 111297119
- Full Text :
- https://doi.org/10.1016/j.intimp.2015.10.035