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Expression of secreted protein acidic and rich in cysteine is an independent prognostic indicator of a poor clinical outcome in oropharyngeal carcinoma patients.
- Source :
-
Acta Oto-Laryngologica . Feb2016, Vol. 136 Issue 2, p189-194. 6p. - Publication Year :
- 2016
-
Abstract
- Conclusion: SPARC-expression is an indicator of the prognosis in terms of OS, independent of HPV-infection. HPV-negative patients with SPARC-Low show survival as favorable as HPV-positive patients, probably because of their higher salvage rate after relapse than SPARC-High patients.Objective: The objectives of the study were to clarify the correlation between the expression of secreted protein acidic and rich in cysteine (SPARC) and HPV-status, and to determine the prognostic value of SPARC-expression in oropharyngeal squamous cell carcinoma (OPSCC) patients.Methods: Fifty-three formalin-fixed and paraffin-embedded tissues were obtained from patients with OPSCC who underwent curative treatment. The SPARC protein was detected by immunohistochemistry. SPARC-expression level was divided into two categories, SPARC-High and SPARC-Low, according to the staining index.Results: Twenty-two out of the 53 OPSCC patients were HPV-positive. There was no significant correlation between the HPV-status and SPARC-expression level. Multivariate Cox proportional hazards regression analysis revealed that the HPV-status and SPARC-expression are independent prognostic indicators of favorable and unfavorable overall survival (OS) (p = 0.021 andp = 0.012), respectively. For disease-free survival, the HPV-status was the only predictive factor (p = 0.022). After stratification by the HPV-status, high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan–Meier analysis and the log-rank test (p = 0.014). Ten out of 28 SPARC-Low patients relapsed, among which six patients (60%) were salvaged. However, 14 out of 25 SPARC-High patients relapsed, and only three patients (21.4%) were salvaged. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *CANCER prognosis
*PROTEIN analysis
*OROPHARYNGEAL cancer
*CONFIDENCE intervals
*FISHER exact test
*IMMUNOHISTOCHEMISTRY
*RESEARCH methodology
*PAPILLOMAVIRUSES
*POLYMERASE chain reaction
*RESEARCH funding
*SURVIVAL analysis (Biometry)
*T-test (Statistics)
*TISSUE culture
*DATA analysis software
*CYSTEINE
*DESCRIPTIVE statistics
*PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00016489
- Volume :
- 136
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Acta Oto-Laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 111336159
- Full Text :
- https://doi.org/10.3109/00016489.2015.1103381