Back to Search
Start Over
IL-9 signaling affects central nervous system resident cells during inflammatory stimuli.
- Source :
-
Experimental & Molecular Pathology . Dec2015, Vol. 99 Issue 3, p570-574. 5p. - Publication Year :
- 2015
-
Abstract
- Interleukin (IL) 9, a dominant cytokine in Th9 cells, has been proven to play a pathogenic role in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), by augmenting T cell activation and differentiation; however, whether IL-9 signaling affects central nervous system (CNS)-resident cells during CNS autoimmunity remains unknown. In the present study, we found that the IL-9 receptor (IL-9R) was highly expressed in astrocytes, oligodendrocyte progenitor cells (OPCs), oligodendrocytes and microglia cells, and that its expression was significantly upregulated in brain and spinal cord during EAE. In addition, IL-9 increased chemokine expression, including CXCL9, CCL20 and MMP3, in primary astrocytes. Although IL-9 had no effect on the proliferation of microglia cells, it decreased OPC proliferation and differentiation when in combination with other pro-inflammatory cytokines, but not with IFN-γ. IL-9 plus IFN-γ promoted OPC proliferation and differentiation. These findings indicate that CNS-restricted IL-9 signaling may be involved in the pathogenesis of MS/EAE, thus providing a potential therapeutic target for future MS/EAE treatment through disruption of CNS cell-specific IL-9 signaling. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00144800
- Volume :
- 99
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Experimental & Molecular Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 111418489
- Full Text :
- https://doi.org/10.1016/j.yexmp.2015.07.010