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An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies.

Authors :
McClorey, Graham
Wood, Matthew J
Source :
Current Opinion in Pharmacology. Oct2015, Vol. 24, p52-58. 7p.
Publication Year :
2015

Abstract

Despite the discovery more than two decades ago that antisense oligonucleotides (ASOs) could be used to modulate protein expression, there have been only two antisense drugs approved for clinical use till date. Despite this low success rate, the antisense field is undergoing resurgence due to the development of more potent and nuclease resistant chemistries, as well as nanoparticle delivery systems that enhance delivery to target tissues. In this review, we introduce the predominant therapeutic strategies in the antisense field whilst highlighting recent clinical findings that demonstrate the significant potential of these approaches for development of novel therapies in several diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14714892
Volume :
24
Database :
Academic Search Index
Journal :
Current Opinion in Pharmacology
Publication Type :
Academic Journal
Accession number :
111421362
Full Text :
https://doi.org/10.1016/j.coph.2015.07.005