Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials.

Authors :: Roshanov, Pavel S.
Dennis, Brittany B.
Source :: Diabetes Research & Clinical Practice. Dec2015, Vol. 110 Issue 3, pe13-e17. 1p.
Publication Year :: 2015
Abstract: Previous studies have offered weak and conflicting evidence regarding the impact of incretin-based oral antihyperglycemic agents on risk of acute pancreatitis. This meta-analysis of three recent mega-trials found an 82% increase in the odds of acute pancreatitis with the use of these agents compared to usual care (95% CI, 1.17-2.82). [ABSTRACT FROM AUTHOR]

Subjects :: *INCRETINS
*PANCREATITIS treatment
*HYPOGLYCEMIC agents
*MEDICAL care
*META-analysis
*RANDOMIZED controlled trials
*THERAPEUTICS
*THERAPEUTIC use of protease inhibitors
*CLINICAL trials
*COMPARATIVE studies
*RESEARCH methodology
*MEDICAL cooperation
*TYPE 2 diabetes
*PANCREATITIS
*RESEARCH
*PROTEASE inhibitors
*EVALUATION research
*RELATIVE medical risk

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