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局部甲氧沙林加紫外线 A 治疗难治性蕈样肉芽肿皮损的初步研究.

Authors :
闫岩
徐晨琛
王涛
刘洁
刘跃华
Source :
Chinese Journal of Oncology. 11/23/2015, Vol. 37 Issue 11, p859-862. 4p.
Publication Year :
2015

Abstract

To evaluate the efficacy and safety of topical PUVA treatment of refractory lesions of mycosis fungoides. Methods From January 2008 to 2014, a total of 10 patients(4 males and 6 females) with mycosis fungoides were treated with topical PUVA in Peking Union Medical College Hospital, including 7 cases in plaque stage and 3 cases in tumor stage. The average number of lesions were 1.9±0.9. The median age of these patients was (46.0±9.4) years. The average course of disease was (12.4±7.7) years. Psoralen was applied topically on treatment area 30 min before total body UVA irradiation treatment, 3 times a week. And the efficiency and safety of the therapy were evaluated. Results All the patients were treated with topical PUVA with a median total dose of (161.60±135.96) J/ cm2 in an average of (18.10±14.61) fractions. Total dose of UVA was (1 953.25±829.73) J/ cm2,and total number of treatment was (261.90± 116.79) fractions. The total treatment time was (45.80±26.64) months. Complete clinical response (CR) rate was 60.0%, partial response (PR) rate was 30.0%, and the overall response rate (CR+PR) was 90.0%. One patient showed no response. No severe acute or chronic side effects were observed. Conclusion Topical PUVA therapy is effective in the treatment of refractory lesions of mycosis fungoides with little severe side effects. [ABSTRACT FROM AUTHOR]

Details

Language :
Chinese
ISSN :
02533766
Volume :
37
Issue :
11
Database :
Academic Search Index
Journal :
Chinese Journal of Oncology
Publication Type :
Academic Journal
Accession number :
111446436
Full Text :
https://doi.org/10.3760/cma.j.issn.0253?3766.2015.11.013