Back to Search
Start Over
Sistemik Isotretinoin Tedavisi Alan Hastalarda Gözyaşı ve Oküler Yüzey Değişiklikleri.
- Source :
-
Turkish Journal of Ophthalmology / Turk Oftalmoloji Dergisi . 10/1/2013, Vol. 43 Issue 5, p309-312. 4p. - Publication Year :
- 2013
-
Abstract
- Purpose: Our aim in this study was to assess the ocular surface and tear film changes in acne vulgaris patients receiving systemic isotretinoin. Material and Method: Twenty-two eyes of 22 patients who received oral isotretinoin (roaccutane®, 0.7 mg/kg/day) for nodular acne vulgaris were enrolled in this prospective study. Tear film break-up time (BUT), Schirmer 1 test scores with anesthesia, ocular surface disease index (OSDI) scores and conjunctival impression cytology scores were recorded before treatment and at 3- and 6-month visits following the beginning of treatment. Results: BUT values decreased and OSDI scores significantly increased at 3 months after treatment (p = 0.007 and p = 0.018, paired samples test). Schirmer scores did not significantly change by isotretinoin treatment. Of 9 eyes with impression cytology specimens, 4 revealed normal conjunctival findings before treatment. At the 3rd month, there was an increase in the scores characterized by decrease of Goblet cells, and at 6 months of treatment, normal conjunctival findings did not exist in any of the patients (p=0.004, Friedman test). Discussion: Systemic isotretinoin treatment can cause alterations in the tear film and cause dry eye symptoms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Turkish
- ISSN :
- 13000659
- Volume :
- 43
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Turkish Journal of Ophthalmology / Turk Oftalmoloji Dergisi
- Publication Type :
- Academic Journal
- Accession number :
- 111530048
- Full Text :
- https://doi.org/10.4274/tjo.87520