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The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo.

Authors :
Yoshimoto, Momoko
Source :
Annals of the New York Academy of Sciences. Dec2015, Vol. 1362 Issue 1, p16-22. 7p.
Publication Year :
2015

Abstract

In the developing mouse embryo, there are several waves of hematopoiesis. Primitive and definitive erythromyeloid lineages appear prior to hematopoietic stem cell (HSC) emergence, and these waves are considered to be transient and support embryonic homeostasis until HSC-derived hematopoiesis is established. However, recent evidence strongly suggests that HSC-independent immune cells, such as tissue macrophages and some innate lymphoid cells, develop in the mouse embryo and persist into postnatal life. Innate type B-1 cells have also been reported to emerge from hemogenic endothelial cells in the extraembryonic yolk sac and para-aortic splanchnopleura, and continue to develop in the fetal liver, even in HSC-deficient mouse embryos. Here, this review discusses B-1 cell development in the context of the layered immune system hypothesis of B lymphopoiesis and the emergence of B-1 cells independent of HSCs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00778923
Volume :
1362
Issue :
1
Database :
Academic Search Index
Journal :
Annals of the New York Academy of Sciences
Publication Type :
Academic Journal
Accession number :
111556435
Full Text :
https://doi.org/10.1111/nyas.12612