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A new class of glycogen phosphorylase inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Nov2003, Vol. 13 Issue 22, p4125. 4p. - Publication Year :
- 2003
-
Abstract
- A new class of diacid analogues that binds at the AMP site not only are very potent but have ∼10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed. [Copyright &y& Elsevier]
- Subjects :
- *GLYCOGEN phosphorylase
*LIVER
*MUSCLES
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 13
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 11173408
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.08.046