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Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?
- Source :
-
Biochimie . Jan2016, Vol. 120, p56-61. 6p. - Publication Year :
- 2016
-
Abstract
- Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F 3 -Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F 4 -Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009084
- Volume :
- 120
- Database :
- Academic Search Index
- Journal :
- Biochimie
- Publication Type :
- Academic Journal
- Accession number :
- 111828096
- Full Text :
- https://doi.org/10.1016/j.biochi.2015.06.010