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Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.
- Source :
-
Fitoterapia . Jan2016, Vol. 108, p55-61. 7p. - Publication Year :
- 2016
-
Abstract
- The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol ( 1 ), 4′-hydroxypaeoniflorigenone ( 2 ) and 4- epi -albiflorin ( 3 ), together with 13 known ones ( 4–16 ). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 108
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 111893174
- Full Text :
- https://doi.org/10.1016/j.fitote.2015.11.011