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Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease.
- Source :
-
Pediatric Nephrology . Feb2016, Vol. 31 Issue 2, p267-277. 11p. 1 Diagram, 4 Charts, 3 Graphs. - Publication Year :
- 2016
-
Abstract
- Background: As cardiovascular factors are the leading cause of mortality in chronic kidney disease (CKD) and as vitamin D deficiency is prevalent in this population, we aimed to examine the effect of oral cholecalciferol on cardiac parameters and biomarkers for endothelial cell activation in children with CKD. Methods: Forty-one children with CKD and 24 healthy subjects free of any underlying cardiac or renal disease with low 25-hydroxyvitamin D3 (25OHD) levels were evaluated using echocardiography basally and following Stoss vitamin D supplementation. The local vascular stiffness and endothelial dysfunction markers were compared among the groups. Results: Initial flow-mediated dilatation (FMD) measurements were lower and local arterial stiffness was significantly higher in patients. After vitamin D supplementation, these improved significantly in patients, while no significant change was observed for the healthy group. Homocysteine showed inverse correlation with baseline vitamin D level in CKD children and von Willebrand factor emerged as an independent risk factor for FMD impairment. Conclusions: Our interventional study revealed the favorable effects of high-dose cholecalciferol on cardiovascular and endothelial parameters, implying the importance of vitamin D supplementation in children with CKD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D deficiency
*CHOLECALCIFEROL
*ACADEMIC medical centers
*ARTERIES
*BIOMARKERS
*VASODILATION
*CARDIOVASCULAR diseases risk factors
*STATISTICAL correlation
*DIETARY supplements
*ECHOCARDIOGRAPHY
*ENDOTHELIUM
*T-test (Statistics)
*MULTIPLE regression analysis
*DATA analysis software
*DESCRIPTIVE statistics
*MANN Whitney U Test
*KRUSKAL-Wallis Test
*ONE-way analysis of variance
*PREVENTION
*THERAPEUTICS
CHRONIC kidney failure complications
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 31
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 111968563
- Full Text :
- https://doi.org/10.1007/s00467-015-3220-5