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Persistent CMV infection after allogeneic hematopoietic stem cell transplantation in a CMV-seronegative donor-to-positive recipient constellation: Development of multidrug resistance in the absence of anti-viral cellular immunity.
- Source :
-
Journal of Clinical Virology . Jan2016, Vol. 74, p57-60. 4p. - Publication Year :
- 2016
-
Abstract
- We describe a case of persistent cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with discordant and high-risk (D−/R+) constellation of CMV serostatus. Despite the use of different and innovative antiviral strategies, viral replication could not be suppressed successfully promoting a protracted CMV colitis associated with severe gastrointestinal graft-versus-host disease (GI GVHD). We illustrate that the development of multidrug viral resistance, the failure to mount a CMV-specific cellular immune response, as confirmed by QuantiFERON ® -CMV (Qiagen) assay, and the refractory GVHD requiring prolonged immunosuppression were the main factors contributing to persistent viral replication and the fulminant unfavorable course. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13866532
- Volume :
- 74
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Virology
- Publication Type :
- Academic Journal
- Accession number :
- 111978075
- Full Text :
- https://doi.org/10.1016/j.jcv.2015.11.033