Association of matrix metalloproteinase-10 polymorphisms with susceptibility to pelvic organ prolapse.

Aim: The aimof this studywas to explore the correlation between geneticmutations in matrix metalloproteinase-10 (MMP-10) and susceptibility to pelvic organ prolapse (POP). Material and Methods: From September 2011 to December 2013, 263 subjects were recruited, including 91 patients with POP (case group) and 172 non-POP patients (control group). Total MMP-10 concentrations in serum were measured by enzyme-linked immunosorbent assay. The genotyping ofMMP-10 was achieved by quantitative real-time polymerase chain reaction. All data were analyzed with SPSS 18.0. Results: We found that parity, menopause, history of total hysterectomy, and family history of POP were all significantly higher in the POP group than in the control group (P=0.017, P=0.046, P=0.0029 and P<0.001, respectively). Serum MMP-10 levels were obviously higher in the POP group than in the control group (P<0.05). In addition, there was a statistically significant difference between the two groups in the distribution frequency of the MMP-10 (rs17435959G/C) genotype (P<0.05). However, the distribution frequency of the MMP-10 (rs17293607C/T) genotype between the two groups showed no significant differences (P>0.05). Furthermore, the patients with parity>2 and postmenopausal women had elevated serum MMP-10 levels, and the patients with parity>2 and postmenopausal women who carried the G/C+C/C genotype in the MMP-10 gene had an increased risk of POP. Conclusion: We support the view that the rs17435959 polymorphism of the MMP-10 gene may be associated with an increased risk of POP. [ABSTRACT FROM AUTHOR]