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Practical problems of measuring depth of submucosal invasion in T1 colorectal carcinomas.

Authors :
Kouyama, Yuta
Kudo, Shin-ei
Miyachi, Hideyuki
Ichimasa, Katsuro
Hisayuki, Tomokazu
Oikawa, Hiromasa
Matsudaira, Shingo
Kimura, Yui
Misawa, Masashi
Mori, Yuichi
Kodama, Kenta
Kudo, Toyoki
Hayashi, Takemasa
Wakamura, Kunihiko
Katagiri, Atsushi
Hidaka, Eiji
Ishida, Fumio
Hamatani, Shigeharu
Source :
International Journal of Colorectal Disease. Jan2016, Vol. 31 Issue 1, p137-146. 10p. 3 Color Photographs, 3 Diagrams, 4 Charts.
Publication Year :
2016

Abstract

Purpose: Submucosal invasion depth (SID) in colorectal carcinoma (CRC) is an important factor in estimating risk of lymph node metastasis, but can be difficult to measure, leading to inadequate or over-extensive treatment. Here, we aimed to clarify the practical aspects of measuring SID in T1 CRC. Methods: We investigated 568 T1 CRCs that were resected surgically at our hospital from April 2001 to December 2013, and relationships between SID and clinicopathological factors, including the means of measurement, lesion morphology, and lymph node metastasis. Results: Of these 568 lesions, the SID was ≥1000 μm in 508 lesions. SIDs for lesions measured from the surface layer were all ≥1000 μm. Although lesions with SIDs ≥1000 μm were associated with significantly higher levels of unfavorable histologic types and lymphovascular infiltration than shallower lesions, a depth of ≥1000 μm was not a significant risk factor for lymph node metastasis (LNM) (6.7 vs. 9.8 %; P = 0.64), and no lesions for which the sole pathological factor was SID ≥1000 μm had lymph node metastasis. Protruded lesions showed deeper SIDs than other types. Conclusions: Although we found several problems of measuring SID in this study, we also found, surprisingly, that SID is not a risk factor for lymph node metastasis, and its measurement is not needed to estimate the risk of lymph node metastasis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01791958
Volume :
31
Issue :
1
Database :
Academic Search Index
Journal :
International Journal of Colorectal Disease
Publication Type :
Academic Journal
Accession number :
112083925
Full Text :
https://doi.org/10.1007/s00384-015-2403-7