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Vilazodone for cannabis dependence: A randomized, controlled pilot trial.
- Source :
-
American Journal on Addictions . Jan2016, Vol. 25 Issue 1, p69-75. 7p. 1 Diagram, 1 Chart, 1 Graph. - Publication Year :
- 2016
-
Abstract
- <bold>Background and Objectives: </bold>The purpose of this study was to evaluate the efficacy of vilazodone, a selective serotonin receptor inhibitor and partial 5-HT1A agonist, for treatment of cannabis dependence.<bold>Methods: </bold>Seventy-six cannabis-dependent adults were randomized to receive either up to 40 mg/day of vilazodone (n = 41) or placebo (n = 35) for 8 weeks combined with a brief motivational enhancement therapy intervention and contingency management to encourage study retention. Cannabis use outcomes were assessed via weekly urine cannabinoid tests; secondary outcomes included cannabis use self-report and cannabis craving.<bold>Results: </bold>Participants in both groups reported reduced self-reported cannabis use over the course of the study; however, vilazodone provided no advantage over placebo in reducing cannabis use. Men had significantly lower creatinine-adjusted cannabinoid levels and a trend for increased negative urine cannabinoid tests than women.<bold>Discussion and Conclusions: </bold>Vilazodone was not more efficacious than placebo in reducing cannabis use. Important gender differences were noted, with women having worse cannabis use outcomes than men.<bold>Scientific Significance: </bold>Further medication development efforts for cannabis use disorders are needed, and gender should be considered as an important variable in future trials. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANNABIS (Genus)
*PHYSIOLOGY
*SUBSTANCE-induced disorders
*SEROTONIN receptors
*CANNABINOIDS
*RANDOMIZED controlled trials
*THERAPEUTICS
*SEROTONIN uptake inhibitors
*COMBINED modality therapy
*COMPARATIVE studies
*HUMAN reproduction
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*RESEARCH funding
*SUBSTANCE abuse
*PILOT projects
*EVALUATION research
*MOTIVATIONAL interviewing
*TREATMENT effectiveness
*BLIND experiment
Subjects
Details
- Language :
- English
- ISSN :
- 10550496
- Volume :
- 25
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- American Journal on Addictions
- Publication Type :
- Academic Journal
- Accession number :
- 112128731
- Full Text :
- https://doi.org/10.1111/ajad.12324