INTERFACIAL REORGANIZATION OF MOLECULAR ASSEMBLIES USED AS DRUG DELIVERY SYSTEMS.

The number of potential applications of nanosized molecular assemblies such as vesicles, nanocapsules, biodegradable polyester matrix and more complex structures in drug research and nanomedicine is rapidly increasing with the developed technologies to tune and control their bulk and mainly surface properties. For a better understanding of nanoparticle behavior at the membrane interfaces an in vitro study of the mechanisms of loss of mechanical stability and their reorganization on various membrane systems seems indispensable. By using the simplest convenient monolayer models the mechanisms of destabilization and reorganization of various classical or modifi ed nanosized molecular assemblies spread or adsorbed on pure air/water interface or at the preformed model membrane were studied. [ABSTRACT FROM AUTHOR]