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An investigation on the anti-tumor properties of FSH-Lytic.
- Source :
-
Journal of Radioanalytical & Nuclear Chemistry . Jan2016, Vol. 307 Issue 1, p89-97. 9p. 2 Color Photographs, 1 Black and White Photograph, 6 Graphs. - Publication Year :
- 2016
-
Abstract
- A new designed hybrid peptide FSH-Lytic was synthesized and expected to combine the follicle stimulating hormone receptor (FSHR) targeting and tumor cell membranes disintegration. Through in vitro and vivo study, no significant enhancement on anti-tumor activity was shown compared with Lytic peptide only. We also prepared F-Al-NOTA-MAL-FSH-Lytic and use microPET image to observe the FSHR targeting of FSH-Lytic. No accumulation in the tumor may explain the failure of FSH-Lytic on cancer therapy. In summary, microPET image can provide more accurate and visible information for screening new anti-tumor agents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 307
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 112155744
- Full Text :
- https://doi.org/10.1007/s10967-015-4143-0