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Cytotoxic T Lymphocyte Antigen-4 Down-Regulates T Helper 1 Cells by Increasing Expression of Signal Transducer and Activator of Transcription 3 in Acute Graft-versus-Host Disease.
- Source :
-
Biology of Blood & Marrow Transplantation . Feb2016, Vol. 22 Issue 2, p212-219. 8p. - Publication Year :
- 2016
-
Abstract
- Numerous previous studies have suggested that cytotoxic T lymphocyte antigen-4 (CTLA-4) plays an important role in acute graft-versus-host disease (GVHD). How CTLA-4 acts in regulating acute GVHD remains unknown, however. In the present study, we found that, compared with healthy controls, CTLA-4 plasma and relative mRNA levels in patients with acute GVHD were initially decreased and then markedly elevated after 28 days of treatment. CTLA-4 levels were higher in patients with grade I-II acute GVHD compared with those with grade III-IV acute GVHD both before and after treatment. Up-regulation of CTLA-4 significantly increased the luciferase activity and degree of phosphorylation of signal transducer and activator of transcription 3 (STAT3). Meanwhile, T cell activation was significantly inhibited, and levels of IFN-γ, IL-17, and IL-22 decreased. These findings suggest that CTLA-4 might be involved in the pathogenesis of acute GVHD, and may down-regulate T helper 1 cells by increasing STAT3 expression in acute GVHD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIGENS
*CYTOPROTECTION
*T cells
*MESSENGER RNA
*GRAFT versus host disease
Subjects
Details
- Language :
- English
- ISSN :
- 10838791
- Volume :
- 22
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biology of Blood & Marrow Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 112265018
- Full Text :
- https://doi.org/10.1016/j.bbmt.2015.11.003