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Laparoscopic Hyperthermic Intraperitoneal Perfusion Chemotherapy for Patients with Malignant Ascites Secondary to Unresectable Gastric Cancer.
- Source :
-
Journal of Laparoendoscopic & Advanced Surgical Techniques . Jan2016, Vol. 26 Issue 1, p32-39. 8p. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>To compare the efficacy of three chemotherapeutic combinations for laparoscopic hyperthermic intraperitoneal perfusion chemotherapy (HIPPC) in the treatment of malignant ascites secondary to unresectable gastric cancer (GC).<bold>Materials and Methods: </bold>From January 2010 to December 2013, 38 GC patients were randomly divided into three groups and treated by laparoscopic HIPPC with one of the three following chemotherapy combinations: raltitrexed (Ra) with oxaliplatin [trans-(±)-diaminocyclohexane oxalatoplatinum (l-OHP)], Ra with cisplatin (DDP), and Ra with mitomycin C (MMC). Perioperative complications, patients' quality of life, and survival were recorded and compared among the three groups.<bold>Results: </bold>The intraoperative course was successful in all patients, and no perioperative death or complication related to laparoscopic HIPPC was documented. The median follow-up period was 9 months, and the median survival was 7.5 months for all patients. Patients in the Ra/l-OHP group had a median survival of 8.7 months, the Ra/DDP group had a median survival of 5.6 months, and the Ra/MMC group had a median survival of 7.5 months. Patients' median survival in the Ra/l-OHP group and Ra/MMC group was significantly longer than in the Ra/DDP group (Pā<ā.05). No significant difference was found in total remission rate of ascites, increase in the Karnofsky Performance Scale, and incidence rate of port-site metastases among the three groups.<bold>Conclusions: </bold>Laparoscopy-assisted HIPPC provides modest yet encouraging efficacy for malignant ascites secondary to disseminated GC. Our preliminary data indicate that the chemotherapeutic combination of Ra/l-OHP and Ra/MMC might be more beneficial compared with Ra/DDP in terms of patients' survival. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LAPAROSCOPIC surgery
*ISOLATION perfusion
*HYPERTHERMIC intraperitoneal chemotherapy
*ASCITES
*STOMACH cancer
*MITOMYCIN C
*PATIENTS
*CANCER complications
*CANCER treatment
*ANTINEOPLASTIC agents
*CANCER
*CANCER chemotherapy
*COMBINED modality therapy
*COMPARATIVE studies
*LAPAROSCOPY
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*STOMACH tumors
*THERMOTHERAPY
*PERITONEUM tumors
*EVALUATION research
*RANDOMIZED controlled trials
*TREATMENT effectiveness
*KARNOFSKY Performance Status
*DISEASE complications
*TUMOR treatment
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 10926429
- Volume :
- 26
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Laparoendoscopic & Advanced Surgical Techniques
- Publication Type :
- Academic Journal
- Accession number :
- 112333608
- Full Text :
- https://doi.org/10.1089/lap.2015.0266