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Hepatic reaction dose for parenchymal changes on Gd-EOB-DTPA-enhanced magnetic resonance images after stereotactic body radiation therapy for hepatocellular carcinoma.
- Source :
-
Journal of Medical Imaging & Radiation Oncology . Feb2016, Vol. 60 Issue 1, p96-101. 6p. - Publication Year :
- 2016
-
Abstract
- <bold>Introduction: </bold>The present study evaluated the threshold dose for hepatic parenchymal changes on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) images after stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC). <bold>Methods: </bold>Twenty patients with available data of follow-up MR images acquired 2-4 months after completion of SBRT were selected among the registered patients. SBRT was performed using multiple coplanar and non-coplanar beams with energies of 6 or 15 MV. All patients were treated with doses of 45 Gy administered in three fractions over 3 consecutive days. For image registration between planning computed tomography (CT) and MR images, landmark-based rigid body registration was performed using MIM software. <bold>Results: </bold>Seventeen patients were included in the analysis. The median discrepancies between planning CT and MR images in the left-right, anterior-posterior and superior-inferior directions were 1.38 mm, 1.24 mm and 1.72 mm, respectively. The median D50 value for the defect in the hepatobiliary phase of Gd-EOB-DTPA-enhanced MR images after SBRT was 19.8 Gy (range, 14.2-28.7 Gy), with R(2) values ranging from 0.76 to 0.99. <bold>Conclusions: </bold>The threshold dose for parenchymal changes in the hepatobiliary phase of Gd-EOB-DTPA-enhanced MR images performed 2-4 months after 45 Gy of SBRT in three fractions was approximately 20 Gy. Our results provide the basis for further research on the functional loss of liver parenchyma after SBRT. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIVER cancer
*DIETHYLENETRIAMINEPENTAACETIC acid
*GADOLINIUM compounds
*STEREOTACTIC radiotherapy
*RADIOTHERAPY treatment planning
*COMPARATIVE studies
*DIAGNOSTIC imaging
*HEPATOCELLULAR carcinoma
*LIVER tumors
*DOSE-response relationship (Radiation)
*MAGNETIC resonance imaging
*RESEARCH methodology
*MEDICAL cooperation
*RADIATION doses
*RADIOSURGERY
*RESEARCH
*EVALUATION research
*TREATMENT effectiveness
*CONTRAST media
*RETROSPECTIVE studies
RESEARCH evaluation
Subjects
Details
- Language :
- English
- ISSN :
- 17549477
- Volume :
- 60
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Medical Imaging & Radiation Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 112506118
- Full Text :
- https://doi.org/10.1111/1754-9485.12393