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Panic disorder and incident coronary heart disease: a systematic review and meta-regression in 1 131 612 persons and 58 111 cardiac events.
- Source :
-
Psychological Medicine . Oct2015, Vol. 45 Issue 14, p2909-2920. 12p. - Publication Year :
- 2015
-
Abstract
- Background. Substantial healthcare resources are devoted to panic disorder (PD) and coronary heart disease (CHD); however, the association between these conditions remains controversial. Our objective was to conduct a systematic review of studies assessing the association between PD, related syndromes, and incident CHD. Method. Relevant studies were retrieved from Medline, EMBASE, SCOPUS and PsycINFO without restrictions from inception to January 2015 supplemented with hand-searching. We included studies that reported hazard ratios (HR) or sufficient data to calculate the risk ratio and 95% confidence interval (CI) which were pooled using a random-effects model. Studies utilizing self-reported CHD were ineligible. Twelve studies were included comprising 1 131 612 persons and 58 111 incident CHD cases. Results. PD was associated with the primary incident CHD endpoint [adjusted HR (aHR) 1.47, 95% CI 1.24-1.74, p < 0.00001] even after excluding angina (aHR 1.49, 95% CI 1.22-1.81, p < 0.00001). High to moderate quality evidence suggested an association with incident major adverse cardiac events (MACE; aHR 1.40, 95% CI 1.16-1.69, p = 0.0004) and myocardial infarction (aHR 1.36, 95% CI 1.12-1.66, p = 0.002). The risk for CHD was significant after excluding depression (aHR 1.64, 95% CI 1.45-1.85) and after depression adjustment (aHR 1.38, 95% CI 1.03-1.87). Age, sex, length of follow-up, socioeconomic status and diabetes were sources of heterogeneity in the primary endpoint. Conclusions. Meta-analysis showed that PD was independently associated with incident CHD, myocardial infarction and MACE; however, reverse causality cannot be ruled out and there was evidence of heterogeneity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CORONARY heart disease risk factors
*MYOCARDIAL infarction risk factors
*CONFIDENCE intervals
*CORONARY disease
*DIABETES
*HEALTH
*MEDICAL information storage & retrieval systems
*PSYCHOLOGY information storage & retrieval systems
*MEDLINE
*META-analysis
*PANIC disorders
*PROBABILITY theory
*SELF-evaluation
*SYSTEMATIC reviews
*BIBLIOGRAPHIC databases
*SOCIOECONOMIC factors
*ANXIETY disorders
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Volume :
- 45
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Psychological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 112639792
- Full Text :
- https://doi.org/10.1017/S0033291715000963