Infecţii orale şi pulmonare cu Candida spp. - studiu retrospectiv.

Intoduction: Oral and pulmonary Candida spp. infections are opportunistic infections. The most frequently affected are the immunosuppressed individuals suffering from HIV, tuberculosis, viral hepatitis infection or cancer. Materials and Methods: This retrospective study was conducted fora period of one year, in a hospital dedicated to infectious diseases. We selected from the database of the clinical microbiology laboratory positive sputum samples for any species of Candida spp., and then we selected the medical records of patients with positive samples diagnoses. Results: We identified 135 samples (aspirate and sputum) positive for Candida spp., from 123 patients. Of the total number of patients, 33 (26.8%) were diagnosed with oral candidiasis and 22 (17.9%) were diagnosed with Candida spp. pulmonary infection. Of the oral candidiasis group, 24 (72.7%) were diagnosed with HIV infection, 7 7 (33.3%) had tuberculosis, 11 (33,3%) had viral hepatitis and 6 (18.2%) had cancer. 7 7 (50%) had pulmonary candidiasis associated with other bacterial infections. 28 strains of Candida spp. were isolated from pulmonary samples, 13 (46,4%) being Candida albicans and 15 (53.6%) Candida non-albicans. Conclusions: Diagnosis and monitoring of the Candida spp. pulmonary infections represents an important issue. It helps to distinguish whether to use or not antifungal treatment considering that resistance to antifungals increased in the last decades. [ABSTRACT FROM AUTHOR]