An efficient preparation of novel epoxyketone intermediates for the synthesis of carfilzomib and its derivatives.

A novel and efficient preparation of epoxyketone intermediates for the synthesis of carfilzomib and its derivatives has been developed. Compared to reported methods, this highly stereoselective, environmentally friendly, low-cost method can be used in scaling up the synthesis of carfilzomib and its derivatives. [ABSTRACT FROM AUTHOR]