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Oct-4 is associated with gastric cancer progression and prognosis.
- Source :
-
OncoTargets & Therapy . Jan2016, Vol. 9, p517-522. 6p. - Publication Year :
- 2016
-
Abstract
- Aim: To investigate the clinical significance of Oct-4 in the development and progression of gastric cancer. Methods: Immunohistochemistry was used to analyze Oct-4 expression in 412 gastric cancer cases. Oct-4 protein levels were upregulated in gastric cancer tissues compared with adjacent noncancerous tissues. Results: Positive expression of Oct-4 correlated with age, depth of invasion, Lauren classification, lymph node metastasis, distant metastasis, and TNM stage. In stages I, II, and III, the 5-year survival rate of patients with high expression of Oct-4 was significantly lower than that in patients with low expression of Oct-4. In stage IV, Oct-4 expression did not correlate with the 5-year survival rate. Furthermore, multivariate analysis suggested that the depth of invasion, lymph node metastasis, distant metastasis, TNM stage, and upregulation of Oct-4 were independent prognostic factors of gastric cancer. Conclusion: Oct-4 protein is a useful marker in predicting tumor progression and prognosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11786930
- Volume :
- 9
- Database :
- Academic Search Index
- Journal :
- OncoTargets & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 112980387
- Full Text :
- https://doi.org/10.2147/OTT.S90031