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A novel method for the synthesis of maxacalcitol.
- Source :
-
Russian Journal of General Chemistry . Jan2016, Vol. 86 Issue 1, p173-177. 5p. 1 Diagram. - Publication Year :
- 2016
-
Abstract
- Maxacalcitol ( 1), a kind of active vitamin D drugs, was prepared from pregnenolone acetate ( 2) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported approaches. The unoptimized overall yield was 0.178%. The structure of all intermediates and final product was confirmed by H NMR, C NMR and MS techniques. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D
*PREGNENOLONE
*DRUG development
*CHEMICAL synthesis
*CHEMICAL reactions
Subjects
Details
- Language :
- English
- ISSN :
- 10703632
- Volume :
- 86
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Russian Journal of General Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 113040802
- Full Text :
- https://doi.org/10.1134/S1070363216010278