Back to Search
Start Over
Killer toxin from several food-derived Debaryomyces hansenii strains effective against pathogenic Candida yeasts.
- Source :
-
International Journal of Food Microbiology . Apr2016, Vol. 222, p23-29. 7p. - Publication Year :
- 2016
-
Abstract
- Candida yeasts are the dominant fungi in the healthy human microbiome, but are well-known for causing disease following a variety of perturbations. Evaluation of fungal populations from the healthy human gut revealed a significant negative correlation between the foodborne yeast, Debaryomyces hansenii , and Candida species. D. hansenii is reported to produce killer toxins (mycocins) effective against other yeast species. In order to better understand this phenomenon, a collection of 42 D. hansenii isolates was obtained from 22 cheeses and evaluated for killer activity against Candida albicans and Candida tropicalis over a range of temperatures and pH values. Twenty three strains demonstrated killer activity against both C. albicans and C. tropicalis , which was pH- and temperature-dependent, with no killer activity observed for any strain at pH 6.5 or higher, or at ≥ 35 °C (physiological conditions in the human gastrointestinal tract). A cell-free mycocin preparation showed transient killer activity against C. albicans at 35 °C and a cheese sample containing a killer D. hansenii strain demonstrated sustained killer activity against both C. albicans and C. tropicalis . Together, these observations raise the possibility that D. hansenii could influence Candida populations in the gut. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DEBARYOMYCES hansenii
*MYCOTOXINS
*FOOD microbiology
*YEAST
*MYCOSES
*PROBIOTICS
Subjects
Details
- Language :
- English
- ISSN :
- 01681605
- Volume :
- 222
- Database :
- Academic Search Index
- Journal :
- International Journal of Food Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 113188173
- Full Text :
- https://doi.org/10.1016/j.ijfoodmicro.2016.01.016