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What's new in osteoarthritis pathogenesis?
- Source :
-
Internal Medicine Journal . Feb2016, Vol. 46 Issue 2, p229-236. 7p. 1 Diagram, 1 Chart. - Publication Year :
- 2016
-
Abstract
- Osteoarthritis is the leading musculoskeletal cause of disability in the Western society. Despite this, it is still difficult to gain a precise definition of what osteoarthritis actually is. The methods used for the study are narrative review and viewpoint focussing on the knee. It is well known that there is a modest correlation between X-ray changes and pain. Improvements in imaging have shown that osteoarthritis should be regarded as an umbrella term for a number of pathophysiological processes leading to pain and/or cartilage loss. If these are inside the joint (such as bone marrow lesions, cartilage defects or meniscal tear) then they can be considered osteoarthritis, while those outside the joint (such as obesity, weak muscles and vitamin D deficiency) could be considered the osteoarthritis syndrome. These improvements in basic science are leading to lesion-specific therapies indicating the importance of trying to pinpoint causes of pain in the individual. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KNEE diseases
*OSTEOARTHRITIS diagnosis
*PAIN diagnosis
*MENISCUS injuries
*KNEE anatomy
*ARTICULAR cartilage
*DIAGNOSTIC imaging
*GENETICS
*INFLAMMATION
*MAGNETIC resonance imaging
*MUSCLE strength
*DIAGNOSIS of musculoskeletal system diseases
*OSTEOARTHRITIS
*VITAMIN D
*WEATHER
*BODY mass index
*PHYSICAL activity
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 14440903
- Volume :
- 46
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Internal Medicine Journal
- Publication Type :
- Academic Journal
- Accession number :
- 113206899
- Full Text :
- https://doi.org/10.1111/imj.12763