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Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins.
- Source :
-
Journal of Virology . Feb2016, Vol. 90 Issue 3, p1682-1686. 5p. - Publication Year :
- 2016
-
Abstract
- Newcastle disease virus (NDV) expressing HIV-1 BaL gp160 was evaluated either alone or with monomeric BaL gp120 and BaL SOSIP gp140 protein in a prime-boost combination in guinea pigs to enhance envelope (Env)-specific humoral and mucosal immune responses. We showed that a regimen consisting of an NDV prime followed by a protein boost elicited stronger serum and mucosal Th-1-biased IgG responses and neutralizing antibody responses than NDV-only immunizations. Additionally, these responses were higher after the gp120 than after the SOSIP gp140 protein boost. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNE response
*NEWCASTLE disease
*HIV prevention
*IMMUNOGLOBULINS
*IMMUNIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 90
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 113257347
- Full Text :
- https://doi.org/10.1128/JVI.02847-15