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Effects of liraglutide on no-reflow in patients with acute ST-segment elevation myocardial infarction.
- Source :
-
International Journal of Cardiology . Apr2016, Vol. 208, p109-114. 6p. - Publication Year :
- 2016
-
Abstract
- Background The ‘no-reflow’ phenomenon after a percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) is a strong predictor of both short- and long-term mortality. Glucagon-like peptide-1 (GLP-1) exerts a cardioprotective effect during ischemia reperfusion injury. We planned to evaluate the effects of liraglutide on myocardial no-reflow after PCI for STEMI. Methods A total of 284 patients with STEMI undergoing PCI were enrolled in this study between September 2013 and March 2015. Of these, 210 patients were randomized 1:1 to receive either liraglutide or placebo 30 min before PCI (1.8 mg). Results The primary end point, the prevalence of no-reflow, was significantly lower in the liraglutide group than in the control group (5% vs. 15%, P = 0.01). Administration of liraglutide was consistently identified as a significant determinant for no-reflow ratio. There was a significant decrease in serum high-sensitivity C-reactive protein levels at 6-hour reperfusion in the liraglutide group compared to the control group (0.87 ± 0.09 mg/dL vs. 0.96 ± 0.10 mg/dL, P < 0.001). During a 3-month follow-up period, no difference was observed in the incidence of major adverse cardiovascular event. Conclusions Liraglutide may be associated with less no-reflow in STEMI, which should be confirmed by larger-scale trials. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01675273
- Volume :
- 208
- Database :
- Academic Search Index
- Journal :
- International Journal of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 113403850
- Full Text :
- https://doi.org/10.1016/j.ijcard.2015.12.009