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Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2016, Vol. 26 Issue 6, p1554-1557. 4p. - Publication Year :
- 2016
-
Abstract
- This Letter describes an efficient ring-closing metathesis approach to 2-chloro-4-amino-pyrimido[4,5- c ]azepines and 2-chloro-4-amino-pyrimido[4,5- c ]oxepines. These chlorides were applied to the synthesis of several potent γ-secretase modulators (GSMs). [ABSTRACT FROM AUTHOR]
- Subjects :
- *PTERIDINES
*AZEPINES
*SECRETASES
*IMMUNOMODULATORS
*METATHESIS reactions
*CHLORIDES
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 26
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 113405252
- Full Text :
- https://doi.org/10.1016/j.bmcl.2016.02.016