Adaptive immune defects in a patient with leukocyte adhesion deficiency type III with a novel mutation in FERMT3.

The article focuses on research related to immune defects in leukocyte adhesion deficiency (LAD). Topics discussed include characterization of LAD through impairment of phagocyte adhesion, identification of a LAD-III patient with a mild clinical phenotype having immunologic defects involving both innate and adaptive immune responses, and treatment of the patient through regular intravenous immunoglobulin (IVIG) therapy.