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Thyroid C-Cell Hyperplasia in an Adolescent with Neurofibromatosis Type 1.
- Source :
-
Hormone Research . 2001, Vol. 56 Issue 1/2, p63-66. 4p. - Publication Year :
- 2001
-
Abstract
- Background: Subjects with neurofibromatosis type 1 (NF1) show an increased risk of endocrine tumors, especially pheochromocytoma, whereas thyroid C-cell hyperplasia (CCH) and medullary thyroid carcinoma (MTC) are very rare events described only in adult patients. Method: A case of CCH diagnosed in a 14-year-old girl affected with NF1 is reported. Calcitonin serum level after pentagastin was elevated (286 pg/ml). Genetic testing was performed in order to rule out mutations in the RET proto-oncogene. Result: No germline mutation previously reported in MEN2 was detected. Multifocal and bilateral CCH was demonstrated by immunohistochemistry. Conclusion: It is suggested that in such a genetic background of high risk for malignancy, CCH could be considered as an extremely rare condition likely preceding MTC.Copyright © 2002 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03010163
- Volume :
- 56
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Hormone Research
- Publication Type :
- Academic Journal
- Accession number :
- 11342926
- Full Text :
- https://doi.org/10.1159/000048092